Genetic Flaw Influences PTSD Severity

A chemical change in a particular gene appears to influence brain development in such a way as to lessen the ability to deal with strong emotions or cope with stressful experiences.

The new research is the first to show that the SKA2 gene plays a role in the development of post-traumatic stress disorder (PTSD).

The gene aberration caused by chemical imbalances appears to cause a thinner cortex in key regions of the brain decreasing brain health and influencing severe PTSD symptoms.

The findings from investigators at Boston University School of Medicine (BUSM), the National Center for PTSD and the Translational Research Center for TBI and Stress Disorders at VA Boston Healthcare System are discussed online in the journal Molecular Psychiatry.